Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro

Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro

Objectives: Many regions of Africa have experienced lower COVID-19 morbidity and mortality than Europe. Pre-existing humoral responses to endemic human coronaviruses (HCoV) may cross-protect against SARS-CoV-2. We investigated the neutralizing capacity of SARS-CoV-2 spike reactive and nonreactive im...

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Bibliographic Details
Main Authors: James Nyagwange, Bernadette Kutima, Kennedy Mwai, Henry K. Karanja, John N. Gitonga, Daisy Mugo, Yiakon Sein, Daniel Wright, Donwilliams O. Omuoyo, Joyce U. Nyiro, James Tuju, D. James Nokes, Ambrose Agweyu, Philip Bejon, Lynette I. Ochola-Oyier, J． Anthony G. Scott, Teresa Lambe, Eunice Nduati, Charles Agoti, George M. Warimwe
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:International Journal of Infectious Diseases
Subjects:
SARS-CoV-2
Human coronaviruses
Pre-existing antibodies
Spike proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971222006336

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http://www.sciencedirect.com/science/article/pii/S1201971222006336

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