Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation

Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation

The [1,2,3]-triazolo [1,5-a] quinoxalin-4(5H)-one scaffold and its analogues triazole-fused heterocyclic compounds are relevant structural templates in both natural and synthetic biologically active compounds. However, their medicinal chemistry applications are often limited due to the lack of synth...

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Bibliographic Details
Main Authors: Sveva Pelliccia, Antonella Ilenia Alfano, Beatriz Ramos Gomes Da Assunção, Luigia Turco, Francesca Lembo, Vincenzo Summa, Elisabetta Buommino, Margherita Brindisi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Chemistry
Subjects:
[1,2,3]-triazolo [1,5-a] quinoxalin-4(5H)-one
privileged scaffold
sustainable synthesis
green chemistry
drug discovery
antimicrobial agents
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1126427/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2023.1126427/full

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