Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish

Abstract Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity (ROHs) that arise when identical-by-...

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Autori principali: Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell
Natura: Articolo
Lingua:English
Pubblicazione: BMC 2023-03-01
Serie:BMC Genomics
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Accesso online:https://doi.org/10.1186/s12864-023-09208-5