Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish

Abstract Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity (ROHs) that arise when identical-by-...

Full description

Bibliographic Details
Main Authors: Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Genomics
Subjects:
Online Access:https://doi.org/10.1186/s12864-023-09208-5