Mesenchymal Stromal Cells: Role in the BM Niche and in the Support of Hematopoietic Stem Cell Transplantation

Abstract. Mesenchymal stromal cells (MSCs) are key elements in the bone marrow (BM) niche where they interact with hematopoietic stem progenitor cells (HSPCs) by offering physical support and secreting soluble factors, which control HSPC maintenance and fate. Although necessary for their maintenance...

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Bibliographic Details
Main Authors: Stefania Crippa, Maria Ester Bernardo
Format: Article
Language:English
Published: Wiley 2018-12-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000151