Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain

Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain

Missense variants in CALM genes encoding the Ca2+-binding protein calmodulin (CaM) cause severe cardiac arrhythmias. The disease mechanisms have been attributed to dysregulation of RyR2, for Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) and/or CaV1.2, for Long-QT Syndrome (LQTS). Rece...

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Bibliographic Details
Main Authors: Malene Brohus, Ana-Octavia Busuioc, Reinhard Wimmer, Mette Nyegaard, Michael Toft Overgaard
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
calmodulin
calmodulinopathy
arrhythmogenic
cardiac ion-channel regulation
calmodulin target binding
experimental variant interpretation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1210140/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1210140/full

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