Survivin Gene Disruption via CRISPR/Cas9 Induces Apoptosis Through Down-regulation of FBXO5 and RRM2 in Prostate Cancer Cell Line PC3

Survivin Gene Disruption via CRISPR/Cas9 Induces Apoptosis Through Down-regulation of FBXO5 and RRM2 in Prostate Cancer Cell Line PC3

Objectives: Prostate cancer (PC) is a complex and heterogeneous disease that arises from both genetic and epigenetic alterations. Survivin acts as a bifunctional controller of apoptosis restraint and is up-regulated in numerous human cancers involving PC. CRISPR/Cas9 was illustrated as a profoundly...

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Bibliographic Details
Main Authors: Leila Farhadi, Shohreh Fakhari, Farzad Soleimani, Ali Jalili
Format: Article
Language:English
Published: Aras Part Medical International Press 2021-07-01
Series:Crescent Journal of Medical and Biological Sciences
Subjects:
prostate cancer
survivin
apoptosis
crispr/cas9
Online Access:http://www.cjmb.org/pdf.php?id=520

Internet

http://www.cjmb.org/pdf.php?id=520

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