GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis

GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis

Hyperplasia and migration of fibroblast-like synoviocytes (FLSs) are the key drivers in the pathogenesis of rheumatoid arthritis (RA) and joint destruction. Abundant Yes-associated protein (YAP), which is a powerful transcription co-activator for proliferative genes, was observed in the nucleus of i...

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Bibliographic Details
Main Authors: Paipai Guo, Ji Jiang, Rui Chu, Feng He, Mingli Ge, Ruhong Fang, Qiuyun Guan, Huijuan Cheng, Chunru Jiang, Tiantian Su, Zhenduo Zhu, Hao Liu, Wei Wei, Shihao Zhang, Qingtong Wang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Rheumatoid arthritis
Fibroblast-like synoviocytes
G protein-coupled receptor kinase 2
Salvador homolog-1
Yes-associated protein
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352300477X

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http://www.sciencedirect.com/science/article/pii/S221138352300477X

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