Hydrogen Sulfide Ameliorates Blood-Spinal Cord Barrier Disruption and Improves Functional Recovery by Inhibiting Endoplasmic Reticulum Stress-Dependent Autophagy

Hydrogen Sulfide Ameliorates Blood-Spinal Cord Barrier Disruption and Improves Functional Recovery by Inhibiting Endoplasmic Reticulum Stress-Dependent Autophagy

Spinal cord injury (SCI) induces the disruption of blood-spinal cord barrier (BSCB), which elicits neurological deficits by triggering secondary injuries. Hydrogen sulfide (H2S) is a gaseous mediator that has been reported to have neuroprotective effect in the central nervous system. However, the re...

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Bibliographic Details
Main Authors: Haoli Wang, Yanqing Wu, Wen Han, Jiawei Li, Kebin Xu, Zhengmao Li, Qingqing Wang, Ke Xu, Yanlong Liu, Ling Xie, Jiang Wu, Huacheng He, Huazi Xu, Jian Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
hydrogen sulfide (H2S)
spinal cord injury (SCI)
blood-spinal cord barrier (BSCB)
ER stress
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00858/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00858/full

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