Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus

Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus

Abstract Background Patients with systemic lupus erythematosus (SLE) have autoantibodies against the L1-encoded open-reading frame 1 protein (ORF1p). Here, we report (i) which immune cells ORF1p emanates from, (ii) which L1 loci are transcriptionally active, (iii) whether the cells express L1-depend...

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Bibliographic Details
Main Authors: Kennedy C. Ukadike, Rayan Najjar, Kathryn Ni, Amanda Laine, Xiaoxing Wang, Alison Bays, Martin S. Taylor, John LaCava, Tomas Mustelin
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Mobile DNA
Subjects:
L1
Retrotransposon
Systemic lupus erythematosus
Neutrophils
Interferon
Online Access:https://doi.org/10.1186/s13100-023-00293-7

Internet

https://doi.org/10.1186/s13100-023-00293-7

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