TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

Abstract Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-dependent PARylation on TET enzymes...

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Bibliographic Details
Main Authors: Anja Tolić, Mirunalini Ravichandran, Jovana Rajić, Marija Đorđević, Miloš Đorđević, Svetlana Dinić, Nevena Grdović, Jelena Arambašić Jovanović, Mirjana Mihailović, Nataša Nestorović, Tomasz P. Jurkowski, Aleksandra S. Uskoković, Melita S. Vidaković
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Epigenetics & Chromatin
Subjects:
DNA demethylation
5-Hydroxymethylcytosine
PARP
TET
PARylation
Online Access:https://doi.org/10.1186/s13072-022-00445-8

Internet

https://doi.org/10.1186/s13072-022-00445-8

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