Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain

Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain

Microglia dynamically monitor the microenvironment of the central nervous system (CNS) by constantly extending and retracting their processes in physiological conditions, and microglia/macrophages rapidly migrate into lesion sites in response to injuries or diseases in the CNS. Consequently, their m...

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Bibliographic Details
Main Authors: Fan Wang, Xiao-Ru Ma, Yang Wu, Yong-Cheng Xu, Hui-Min Gu, Di-Xian Wang, Zhao-Jun Dong, Hui-Liang Li, Li-Bin Wang, Jing-Wei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
voltage-gated proton channel
Hv1/HVCN1
voltage sensor domain only protein/VSOP
microglia/macrophages
migration
myelin phagocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.768059/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.768059/full

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