Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease

Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease

Evidence from human neuropathological studies indicates that the levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are compromised in Alzheimer's disease. However, the causes and temporal (pathology-dependent) evolution of these alterations are n...

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Bibliographic Details
Main Authors: M. Florencia Iulita, M. Beatriz Bistué Millón, Rowan Pentz, Lisi Flores Aguilar, Sonia Do Carmo, Simon Allard, Bernadeta Michalski, Edward N. Wilson, Adriana Ducatenzeiler, Martin A. Bruno, Margaret Fahnestock, A. Claudio Cuello
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid-β
Cholinergic
Nerve growth factor
proNGF
BDNF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302097

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http://www.sciencedirect.com/science/article/pii/S0969996117302097

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