Respiratory and Intramuscular Immunization With ChAdOx2-NPM1-NA Induces Distinct Immune Responses in H1N1pdm09 Pre-Exposed Pigs

Respiratory and Intramuscular Immunization With ChAdOx2-NPM1-NA Induces Distinct Immune Responses in H1N1pdm09 Pre-Exposed Pigs

There is a critical need to develop superior influenza vaccines that provide broader protection. Influenza vaccines are traditionally tested in naive animals, although humans are exposed to influenza in the first years of their lives, but the impact of prior influenza exposure on vaccine immune resp...

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Bibliographic Details
Main Authors: Eleni Vatzia, Elizabeth R. Allen, Tanuja Manjegowda, Susan Morris, Adam McNee, Veronica Martini, Reshma Kaliath, Marta Ulaszewska, Amy Boyd, Basudev Paudyal, Veronica B. Carr, Tiphany Chrun, Emmanuel Maze, Ronan MacLoughlin, Pauline M. van Diemen, Helen E. Everett, Teresa Lambe, Sarah C. Gilbert, Elma Tchilian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
influenza A
pig
vaccine
pre-exposure
pdmH1N1
aerosol
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.763912/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.763912/full

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