Neuron-specific enolase promotes stem cell-like characteristics of small-cell lung cancer by downregulating NBL1 and activating the BMP2/Smad/ID1 pathway

Neuron-specific enolase promotes stem cell-like characteristics of small-cell lung cancer by downregulating NBL1 and activating the BMP2/Smad/ID1 pathway

Abstract Little is known about the biological functions of neuron-specific enolase (NSE) as a specific biomarker for small-cell lung cancer (SCLC). Herein, we elucidate the effect and mechanism of NSE on SCLC stem cell-like characteristics. Upregulated NSE expression was observed in spheroid cells....

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Bibliographic Details
Main Authors: Lin Lu, Zhiqiang Zha, Peiling Zhang, Peipei Wang, Xia Liu, Xisheng Fang, Chengyin Weng, Baoxiu Li, Haibo Mao, Lina Wang, Mingmei Guan, Yong Wu, Zhixiang Xu, Zhongqiu Liu, Guolong Liu
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-022-00396-5

Internet

https://doi.org/10.1038/s41389-022-00396-5

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