Ca2+ Requirements for Long-Term Depression Are Frequency Sensitive in Purkinje Cells

Ca2+ Requirements for Long-Term Depression Are Frequency Sensitive in Purkinje Cells

Cerebellar long-term depression (LTD) is a form of synaptic plasticity dependent on postsynaptic Ca2+ changes. One fundamental question is how LTD is selectively induced by specific numbers of Ca2+ pulses and which are the frequency and duration of this train of pulses required for LTD induction. Th...

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Bibliographic Details
Main Authors: C. G. Zamora Chimal, Erik De Schutter
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
calcium requirements
frequency sensitive
long-term depression
cerebellum
CaMKII
stochastic simulation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00438/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00438/full

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