A Small Molecule–Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an α<sub>V</sub>ß<sub>3</sub> Binder for the Treatment of Multiple Cancer Types

A Small Molecule–Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an α<sub>V</sub>ß<sub>3</sub> Binder for the Treatment of Multiple Cancer Types

To improve tumor selectivity of cytotoxic agents, we designed VIP236, a small molecule–drug conjugate consisting of an α<sub>V</sub>β<sub>3</sub> integrin binder linked to a modified camptothecin payload (VIP126), which is released by the enzyme neutrophil elastase (NE) in th...

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Bibliographic Details
Main Authors: Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Charlotte Kopitz, Melanie Heroult, Dmitry Zubov, Joerg Willuda, Thomas Schlange, Antje Kahnert, Harvey Wong, Raquel Izumi, Ahmed Hamdy
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
α<sub>V</sub>β<sub>3</sub> integrin
camptothecin payload
neutrophil elastase
small molecule–drug conjugate
SMDC
SN38 derivative
Online Access:https://www.mdpi.com/2072-6694/14/2/391

Internet

https://www.mdpi.com/2072-6694/14/2/391

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