Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

Reduced IGF-1 signaling increases longevity in many organisms. Here, Mao et al. show that administration of an anti-IGF-1R antibody is well tolerated and delays aging in female mice; importantly, late-life targeting is sufficient to achieve the beneficial effects.

Bibliographic Details
Main Authors: Kai Mao, Gabriela Farias Quipildor, Tahmineh Tabrizian, Ardijana Novaj, Fangxia Guan, Ryan O. Walters, Fabien Delahaye, Gene B. Hubbard, Yuji Ikeno, Keisuke Ejima, Peng Li, David B. Allison, Hossein Salimi-Moosavi, Pedro J. Beltran, Pinchas Cohen, Nir Barzilai, Derek M. Huffman
Format: Article
Language:English
Published: Nature Portfolio 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04805-5

Internet

https://doi.org/10.1038/s41467-018-04805-5

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