Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis

Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis

IntroductionThe mechanisms underlying high drug resistance and relapse rates after multi-modal treatment in patients with colorectal cancer (CRC) and liver metastasis (LM) remain poorly understood.ObjectiveWe evaluate the potential translational implications of intra-patient heterogeneity (IPH) comp...

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Bibliographic Details
Main Authors: Ioannis D. Kyrochristos, Georgios K. Glantzounis, Anna Goussia, Alexia Eliades, Achilleas Achilleos, Kyriakos Tsangaras, Irene Hadjidemetriou, Marilena Elpidorou, Marios Ioannides, George Koumbaris, Michail Mitsis, Philippos C. Patsalis, Dimitrios Roukos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
actionable mutations
circulating variability
comprehensive intra-patient heterogeneity
intratumor heterogeneity
next-generation sequencing
precision cancer medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.855463/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.855463/full

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