Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder

Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in a rare neurodevelopmental disorder characterized by early-onset seizures, severe developmental delay, intellectual disability and Rett syndrome-like features. CDKL5 is highly expressed in the brain during e...

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Bibliographic Details
Main Authors: Claudia Fuchs, Roberto Rimondini, Rocchina Viggiano, Stefania Trazzi, Marianna De Franceschi, Renata Bartesaghi, Elisabetta Ciani
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
CDKL5 disorder
Encephalopathy
Pharmacotherapy
GSK3β inhibitor
Rescue of hippocampal developmental
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300036

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http://www.sciencedirect.com/science/article/pii/S0969996115300036

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