Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administered in children with hemato-oncological diseases

Eight-year national multicenter experience on the use of glucarpidase as effective rescue therapy for delayed methotrexate elimination after high-dose methotrexate cycles administered in children with hemato-oncological diseases

Background: High-dose methotrexate (HDMTX) for cancer treatment can be complicated by delayed methotrexate elimination (DME) and associated acute kidney injury (AKI). This study evaluated glucarpidase for the treatment of DME and HDMTX-AKI in pediatric hemato-oncology patients. Methods: This multice...

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Bibliographic Details
Main Authors: Nicolò Peccatori, Marta Coppola, Antonella Colombini, Daniela Silvestri, Nicoletta Bertorello, Valentina Kiren, Fraia Melchionda, Rosamaria Mura, Daniela Onofrillo, Simona Gobbi, Raffaele Mattera, Luciana Vinti, Tommaso Casini, Nicola Santoro, Domenico Sperlì, Carmelita D’Ippolito, Valentino Conter, Andrea Biondi, Carmelo Rizzari
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EJC Paediatric Oncology
Subjects:
Methotrexate
Glucarpidase
Carboxypeptidase G2
Delayed methotrexate elimination
Acute kidney injury
Acute lymphoblastic leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2772610X2400062X

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http://www.sciencedirect.com/science/article/pii/S2772610X2400062X

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