Sequence dependencies and mutation rates of localized mutational processes in cancer

Sequence dependencies and mutation rates of localized mutational processes in cancer

Abstract Background Cancer mutations accumulate through replication errors and DNA damage coupled with incomplete repair. Individual mutational processes often show nucleotide sequence and functional region preferences. As a result, some sequence contexts mutate at much higher rates than others, wit...

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Bibliographic Details
Main Authors: Gustav Alexander Poulsgaard, Simon Grund Sørensen, Randi Istrup Juul, Morten Muhlig Nielsen, Jakob Skou Pedersen
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Genome Medicine
Subjects:
Pan-cancer
Mutational processes
Hotspots
Mutation rate
Online Access:https://doi.org/10.1186/s13073-023-01217-z

Internet

https://doi.org/10.1186/s13073-023-01217-z

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