The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway

The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway

Abstract Background The ATM kinase constitutes a master regulatory hub of DNA damage and activates the p53 response pathway by phosphorylating the MDM2 protein, which develops an affinity for the p53 mRNA secondary structure. Disruption of this interaction prevents the activation of the nascent p53....

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Bibliographic Details
Main Authors: Konstantinos Karakostis, Laurence Malbert-Colas, Aikaterini Thermou, Borek Vojtesek, Robin Fåhraeus
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Molecular Cancer
Subjects:
MDM2
Synonymous mutations
RNA secondary structure
Genotoxic stress
MRN complex
DNA Damage Sensing
Online Access:https://doi.org/10.1186/s12943-024-01933-z

Internet

https://doi.org/10.1186/s12943-024-01933-z

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