Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3

Mitochondrial haplogroup G is associated with nonalcoholic fatty liver disease, while haplogroup A mitigates the effects of PNPLA3

Abstract Objectives Mitochondrial dysfunction plays a pivotal role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). We hypothesized that mitochondrial DNA (mtDNA) haplogroups affect the risk of NAFLD in Han Chinese patients and interact with PNPLA3 genotypes. Design NAFLD and control...

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Bibliographic Details
Main Authors: Aaron M. Gusdon, You Hui, Jing Chen, Clayton E. Mathews, Shen Qu
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Endocrinology, Diabetes & Metabolism
Subjects:
haplogroups
mitochondria
NAFLD
PNPLA3
Online Access:https://doi.org/10.1002/edm2.187

Internet

https://doi.org/10.1002/edm2.187

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