<i>Trypanosoma brucei</i> Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity

<i>Trypanosoma brucei</i> Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity

Dynamic post-translational modifications allow the rapid, specific, and tunable regulation of protein functions in eukaryotic cells. <i>S</i>-acylation is the only reversible lipid modification of proteins, in which a fatty acid, usually palmitate, is covalently attached to a cysteine re...

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Bibliographic Details
Main Authors: Robert W. B. Brown, Aabha I. Sharma, Miguel Rey Villanueva, Xiaomo Li, Ouma Onguka, Leeor Zilbermintz, Helen Nguyen, Ben A. Falk, Cheryl L. Olson, Joann M. Taylor, Conrad L. Epting, Rahul S. Kathayat, Neri Amara, Bryan C. Dickinson, Matthew Bogyo, David M. Engman
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pathogens
Subjects:
trypanosome
<i>Trypanosoma brucei</i>
post-translational modification
palmitoylation
depalmitoylation
alpha/beta hydrolase
Online Access:https://www.mdpi.com/2076-0817/11/11/1245

Internet

https://www.mdpi.com/2076-0817/11/11/1245

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