High-Throughput Measure of Mitochondrial Superoxide Levels as a Marker of Coronary Artery Disease to Accelerate Drug Translation in Patient-Derived Endothelial Cells Using Opera Phenix<sup>®</sup> Technology

High-Throughput Measure of Mitochondrial Superoxide Levels as a Marker of Coronary Artery Disease to Accelerate Drug Translation in Patient-Derived Endothelial Cells Using Opera Phenix<sup>®</sup> Technology

Improved human-relevant preclinical models of coronary artery disease (CAD) are needed to improve translational research and drug discovery. Mitochondrial dysfunction and associated oxidative stress contribute to endothelial dysfunction and are a significant factor in the development and progression...

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Bibliographic Details
Main Authors: Weiqian E. Lee, Marie Besnier, Elijah Genetzakis, Owen Tang, Katharine A. Kott, Stephen T. Vernon, Michael P. Gray, Stuart M. Grieve, Michael Kassiou, Gemma A. Figtree
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
high-content imaging
high-throughput screening
endothelial dysfunction
endothelial colony-forming cells
drug screening
Online Access:https://www.mdpi.com/1422-0067/25/1/22

Internet

https://www.mdpi.com/1422-0067/25/1/22

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