Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mammalian grainyhead-like (Grhl1-3) genes play key roles in a number of tissue fusion processes including neurulation, epidermal wound healing and eyelid fusion. One family me...

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Bibliographic Details
Main Authors: Marina R. Carpinelli, Michael E. de Vries, Alana Auden, Tariq Butt, Zihao Deng, Darren D. Partridge, Lee B. Miles, Smitha R. Georgy, Jody J. Haigh, Charbel Darido, Simone Brabletz, Thomas Brabletz, Marc P. Stemmler, Sebastian Dworkin, Stephen M. Jane
Format: Article
Language:English
Published: The Company of Biologists 2020-03-01
Series:Disease Models & Mechanisms
Subjects:
grhl2
zeb1
palate
emt
explant
Online Access:http://dmm.biologists.org/content/13/3/dmm042218

Internet

http://dmm.biologists.org/content/13/3/dmm042218

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