Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer’s disease

Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer’s disease

Beta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer’s disease (AD), are believed to spread through connected regions of the brain. Combining diffusion imaging and positron emission tomography, we investigated associations between white matter microstructure specifically in bu...

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Bibliographic Details
Main Authors: Alexa Pichet Binette, Guillaume Theaud, François Rheault, Maggie Roy, D Louis Collins, Johannes Levin, Hiroshi Mori, Jae Hong Lee, Martin Rhys Farlow, Peter Schofield, Jasmeer P Chhatwal, Colin L Masters, Tammie Benzinger, John Morris, Randall Bateman, John CS Breitner, Judes Poirier, Julie Gonneaud, Maxime Descoteaux, Sylvia Villeneuve, DIAN Study Group, PREVENT-AD Research Group
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
PET
diffusion MRI
free-water
uncinate fasciculus
cingulum
Online Access:https://elifesciences.org/articles/62929

Internet

https://elifesciences.org/articles/62929

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