Real-Time Characterization of Clonal Fate Decisions in Complex Leukemia Samples by Fluorescent Genetic Barcoding

Clonal heterogeneity in acute myeloid leukemia (AML) forms the basis for treatment failure and relapse. Attempts to decipher clonal evolution and clonal competition primarily depend on deep sequencing approaches. However, this prevents the experimental confirmation of the identified disease-relevant...

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Bibliographic Details
Main Authors: Tobias Maetzig, Anna Lieske, Nicole Dörpmund, Michael Rothe, Marc-Jens Kleppa, Violetta Dziadek, Jacob Jalil Hassan, Julia Dahlke, Dorit Borchert, Axel Schambach
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/11/24/4045