Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing

Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing

Scarring is associated with significant morbidity. The mechanical signaling factor yes-associated protein (YAP) has been linked to Engrailed-1 (En1)-lineage positive fibroblasts (EPFs), a pro-scarring fibroblast lineage, establishing a connection between mechanotransduction and fibrosis. In this stu...

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Bibliographic Details
Main Authors: Mengfan Wu, Dany Y. Matar, Zhen Yu, Ziyu Chen, Samuel Knoedler, Brian Ng, Oliver A. Darwish, Sadaf Sohrabi, Leigh Friedman, Valentin Haug, George F. Murphy, Yuval Rinkevich, Dennis P. Orgill, Adriana C. Panayi
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
wound healing
fibrosis
scarring
NPWT
mechanotransduction
YAP
Online Access:https://www.mdpi.com/1999-4923/14/10/2125

Internet

https://www.mdpi.com/1999-4923/14/10/2125

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