Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications

Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications

SARS-CoV-2 exploits the respiratory tract epithelium including lungs as the primary entry point and reaches other organs through hematogenous expansion, consequently causing multiorgan injury. Viral E protein interacts with cell junction-associated proteins PALS1 or ZO-1 to gain massive penetration...

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Bibliographic Details
Main Authors: Qiangmin Zhang, Peter A. Friedman
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
PDZ interaction
viral cell entry
GPCR signaling
drug development
Online Access:https://www.mdpi.com/1422-0067/22/20/10963

Internet

https://www.mdpi.com/1422-0067/22/20/10963

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