Epigenetic reprogramming shapes the cellular landscape of schwannoma

Epigenetic reprogramming shapes the cellular landscape of schwannoma

Abstract Mechanisms specifying cancer cell states and response to therapy are incompletely understood. Here we show epigenetic reprogramming shapes the cellular landscape of schwannomas, the most common tumors of the peripheral nervous system. We find schwannomas are comprised of 2 molecular groups...

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Main Authors: S. John Liu, Tim Casey-Clyde, Nam Woo Cho, Jason Swinderman, Melike Pekmezci, Mark C. Dougherty, Kyla Foster, William C. Chen, Javier E. Villanueva-Meyer, Danielle L. Swaney, Harish N. Vasudevan, Abrar Choudhury, Joanna Pak, Jonathan D. Breshears, Ursula E. Lang, Charlotte D. Eaton, Kamir J. Hiam-Galvez, Erica Stevenson, Kuei-Ho Chen, Brian V. Lien, David Wu, Steve E. Braunstein, Penny K. Sneed, Stephen T. Magill, Daniel Lim, Michael W. McDermott, Mitchel S. Berger, Arie Perry, Nevan J. Krogan, Marlan R. Hansen, Matthew H. Spitzer, Luke Gilbert, Philip V. Theodosopoulos, David R. Raleigh
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40408-5

Internet

https://doi.org/10.1038/s41467-023-40408-5

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