Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus

Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus

ABSTRACT To transfer the viral genome into the host cell cytoplasm, internalized influenza A virus (IAV) particles depend on the fusion of the IAV envelope with host endosomal membranes. The antiviral host interferon (IFN) response includes the upregulation of interferon-induced transmembrane protei...

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Bibliographic Details
Main Authors: Alexander Kühnl, Agnes Musiol, Nicole Heitzig, Danielle E. Johnson, Christina Ehrhardt, Thomas Grewal, Volker Gerke, Stephan Ludwig, Ursula Rescher
Format: Article
Language:English
Published: American Society for Microbiology 2018-09-01
Series:mBio
Subjects:
IFITM3
influenza A virus
annexin A6
interferon
late endosomal cholesterol content
Online Access:https://journals.asm.org/doi/10.1128/mBio.01345-18

Internet

https://journals.asm.org/doi/10.1128/mBio.01345-18

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