Mitochondrial DNA: Distribution, Mutations, and Elimination
Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many proteins to form a nucleoid that uniformly distributes within the mitochondrial matrix, which is essential for mitochondrial f...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-04-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/8/4/379 |
| _version_ | 1797715104318357504 |
|---|---|
| author | Chaojun Yan Xiaoying Duanmu Ling Zeng Bing Liu Zhiyin Song |
| author_facet | Chaojun Yan Xiaoying Duanmu Ling Zeng Bing Liu Zhiyin Song |
| author_sort | Chaojun Yan |
| collection | DOAJ |
| description | Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many proteins to form a nucleoid that uniformly distributes within the mitochondrial matrix, which is essential for mitochondrial functions. Defects or mutations of mtDNA result in a range of diseases. Damaged mtDNA could be eliminated by mitophagy, and all paternal mtDNA are degraded by endonuclease G or mitophagy during fertilization. In this review, we describe the role and mechanism of mtDNA distribution and elimination. In particular, we focus on the regulation of paternal mtDNA elimination in the process of fertilization. |
| first_indexed | 2024-03-12T08:01:56Z |
| format | Article |
| id | doaj.art-6c417b6e17b842259b5299d2c82f8dcb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:01:56Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6c417b6e17b842259b5299d2c82f8dcb2023-09-02T19:47:27ZengMDPI AGCells2073-44092019-04-018437910.3390/cells8040379cells8040379Mitochondrial DNA: Distribution, Mutations, and EliminationChaojun Yan0Xiaoying Duanmu1Ling Zeng2Bing Liu3Zhiyin Song4Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaMitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many proteins to form a nucleoid that uniformly distributes within the mitochondrial matrix, which is essential for mitochondrial functions. Defects or mutations of mtDNA result in a range of diseases. Damaged mtDNA could be eliminated by mitophagy, and all paternal mtDNA are degraded by endonuclease G or mitophagy during fertilization. In this review, we describe the role and mechanism of mtDNA distribution and elimination. In particular, we focus on the regulation of paternal mtDNA elimination in the process of fertilization.https://www.mdpi.com/2073-4409/8/4/379mitochondriamtDNAmitophagymtDNA distributionmitochondrial dynamics |
| spellingShingle | Chaojun Yan Xiaoying Duanmu Ling Zeng Bing Liu Zhiyin Song Mitochondrial DNA: Distribution, Mutations, and Elimination Cells mitochondria mtDNA mitophagy mtDNA distribution mitochondrial dynamics |
| title | Mitochondrial DNA: Distribution, Mutations, and Elimination |
| title_full | Mitochondrial DNA: Distribution, Mutations, and Elimination |
| title_fullStr | Mitochondrial DNA: Distribution, Mutations, and Elimination |
| title_full_unstemmed | Mitochondrial DNA: Distribution, Mutations, and Elimination |
| title_short | Mitochondrial DNA: Distribution, Mutations, and Elimination |
| title_sort | mitochondrial dna distribution mutations and elimination |
| topic | mitochondria mtDNA mitophagy mtDNA distribution mitochondrial dynamics |
| url | https://www.mdpi.com/2073-4409/8/4/379 |
| work_keys_str_mv | AT chaojunyan mitochondrialdnadistributionmutationsandelimination AT xiaoyingduanmu mitochondrialdnadistributionmutationsandelimination AT lingzeng mitochondrialdnadistributionmutationsandelimination AT bingliu mitochondrialdnadistributionmutationsandelimination AT zhiyinsong mitochondrialdnadistributionmutationsandelimination |