AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation

Abstract Background The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific transcriptional programs remain unknown. Results We employed a proteomic a...

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Bibliographic Details
Main Authors: Deniz Uğurlu-Çimen, Deniz Odluyurt, Kenan Sevinç, Nazlı Ezgi Özkan-Küçük, Burcu Özçimen, Deniz Demirtaş, Eray Enüstün, Can Aztekin, Martin Philpott, Udo Oppermann, Nurhan Özlü, Tamer T. Önder
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Epigenetics & Chromatin
Subjects:
AF10
DOT1L
BioID
Reprogramming
iPSC
H3K79 methylation
Online Access:https://doi.org/10.1186/s13072-021-00406-7

Internet

https://doi.org/10.1186/s13072-021-00406-7

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