A Porcine Model of Heart Failure With Preserved Ejection Fraction Induced by Chronic Pressure Overload Characterized by Cardiac Fibrosis and Remodeling

Heart failure is induced by multiple pathological mechanisms, and current therapies are ineffective against heart failure with preserved ejection fraction (HFpEF). As there are limited animal models of HFpEF, its underlying mechanisms have not yet been elucidated. Here, we employed the descending ao...

Full description

Bibliographic Details
Main Authors: Weijiang Tan, Xiang Li, Shuang Zheng, Xiaohui Li, Xiaoshen Zhang, W. Glen Pyle, Honghua Chen, Jian Wu, Huan Sun, Yunzeng Zou, Peter H. Backx, Feng Hua Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.677727/full