Late emergence of A594V and L595W mutations related to ganciclovir resistance in a patient with HCMV retinitis and long-term HIV progression

Late emergence of A594V and L595W mutations related to ganciclovir resistance in a patient with HCMV retinitis and long-term HIV progression

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The emergence of ganciclovir (GCV) resistance during the treatment of human cytomegalovirus (HCMV) infection is a serious clinical challenge, and is associated with high morbidity and mortality. In this case report, we describe the emergence of two consecutive mutations (A594V and L595W) related to...

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Bibliographic Details
Main Authors: S.N. Slavov, F.C. Vilar, V.M.D. Wagatsuma, R.C. Santana, A.A. Machado, B.A.L. da Fonseca, S. Kashima, D.T. Covas
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2015-08-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Human cytomegalovirus
HCMV
Ganciclovir
Resistance
AIDS
Online Access:http://www.scielo.br/pdf/bjmbr/v48n9/1414-431X-bjmbr-1414-431X20154507.pdf

Internet

http://www.scielo.br/pdf/bjmbr/v48n9/1414-431X-bjmbr-1414-431X20154507.pdf

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