G-quadruplexes Stabilization Upregulates CCN1 and Accelerates Aging in Cultured Cerebral Endothelial Cells

G-quadruplexes Stabilization Upregulates CCN1 and Accelerates Aging in Cultured Cerebral Endothelial Cells

Senescence in the cerebral endothelium has been proposed as a mechanism that can drive dysfunction of the cerebral vasculature, which precedes vascular dementia. Cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) is a matricellular protein secreted by cerebral endothelial cells (CEC). CCN1 induces sen...

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Bibliographic Details
Main Authors: Brian Noh, Maria P. Blasco-Conesa, Yun-Ju Lai, Bhanu Priya Ganesh, Akihiko Urayama, Ines Moreno-Gonzalez, Sean P. Marrelli, Louise D. McCullough, Jose Felix Moruno-Manchon
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Aging
Subjects:
senescence
endothelial cells
G-quadruplex
aging
CCN1
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2021.797562/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2021.797562/full

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