<i>Pisum sativum</i> Defensin 1 Eradicates Mouse Metastatic Lung Nodules from B16F10 Melanoma Cells

<i>Pisum sativum</i> Defensin 1 Eradicates Mouse Metastatic Lung Nodules from B16F10 Melanoma Cells

<i>Ps</i>d1 is a pea plant defensin which can be actively expressed in <i>Pichia pastoris</i> and shows broad antifungal activity. This activity is dependent on fungal membrane glucosylceramide (GlcCer), which is also important for its internalization, nuclear localization, a...

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Bibliographic Details
Main Authors: Virginia Sara Grancieri do Amaral, Stephanie Alexia Cristina Silva Santos, Paula Cavalcante de Andrade, Jenifer Nowatzki, Nilton Silva Júnior, Luciano Neves de Medeiros, Lycia Brito Gitirana, Pedro Geraldo Pascutti, Vitor H. Almeida, Robson Q. Monteiro, Eleonora Kurtenbach
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
metastasis model of B16F10 melanoma
<i>Pisum sativum</i> defensin 1 (<i>Ps</i>d1)
anti-metastatic activity
glucosylceramide (GlcCer)
cyclin F
Online Access:https://www.mdpi.com/1422-0067/21/8/2662

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https://www.mdpi.com/1422-0067/21/8/2662

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