Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

Aminoglycosides force read through of premature stop codon mutations and introduce new mutation-specific gene-corrective strategies in Duchenne muscular dystrophy. A chronic treatment with gentamicin (32 mg/kg/daily i.p., 8–12 weeks) was performed in exercised mdx mice with the dual aim to clarify t...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Annamaria De Luca, Beatrice Nico, Jean-François Rolland, Anna Cozzoli, Rosa Burdi, Domenica Mangieri, Viviana Giannuzzi, Antonella Liantonio, Valentina Cippone, Michela De Bellis, Grazia Paola Nicchia, Giulia Maria Camerino, Antonio Frigeri, Maria Svelto, Diana Conte Camerino
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier 2008-11-01
Schriftenreihe:Neurobiology of Disease
Schlagworte:
Muscular dystrophy
Gentamicin treatment
Exercise
Dystrophin
Aquaporin-4
Histology
Online Zugang:http://www.sciencedirect.com/science/article/pii/S0969996108001575

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http://www.sciencedirect.com/science/article/pii/S0969996108001575

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