Host sex disparity and viral genotype dependence of the glycosylation level of small Hepatitis B surface protein in patients with HBeAg-positive chronic Hepatitis B

Abstract Background Hepatitis B surface antigen (HBsAg) consists of six components of large/middle/small HBs proteins (L/M/SHBs) with non-glycosylated (ng)- or glycosylated (g)- isomers at sN146 in their shared S domain. g-SHBs plays a crucial role in hepatitis B virus (HBV) secretion. However, the...

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Bibliographic Details
Main Authors: Guomin Ou, Chengyu Zhao, Juan Deng, Hui Zhuang, Kuanhui Xiang, Tong Li
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Virology Journal
Subjects:
Online Access:https://doi.org/10.1186/s12985-023-02096-x