Saikosaponin D reverses epinephrine- and norepinephrine-induced gemcitabine resistance in intrahepatic cholangiocarcinoma by downregulating ADRB2/glycolysis signaling

Saikosaponin D reverses epinephrine- and norepinephrine-induced gemcitabine resistance in intrahepatic cholangiocarcinoma by downregulating ADRB2/glycolysis signaling

Intrahepatic cholangiocarcinoma (iCCA) is a highly fatal malignancy with rapidly increasing incidence and mortality worldwide. Currently, gemcitabine-based systemic chemotherapy is the main clinical therapeutic regimen; however, its efficac...

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Bibliographic Details
Main Authors: He Hui, Guo Jiaqi, Hu Yunxiang, Zhang Han, Li Xinyang, Zhang Jian, Jin Shi
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-07-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
saikosaponin D
gemcitabine resistance
intrahepatic cholangiocarcinoma
ADRB2
glycolysis
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023040

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https://www.sciengine.com/doi/10.3724/abbs.2023040

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