α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies

Abstract α-Synucleinopathies, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-synuclein (αSyn), referred to as Lewy bodies or oligodendroglial cytoplasmic inclu...

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Bibliographic Details
Main Authors: Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zerr
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Translational Neurodegeneration
Subjects:
α-synucleinopathies
α-synuclein
RT-QuIC
Protein strains
Online Access:https://doi.org/10.1186/s40035-023-00342-4

Internet

https://doi.org/10.1186/s40035-023-00342-4

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