Noscapine hydrochloride (benzyl-isoquinoline alkaloid) effectively prevents protein denaturation through reduction of IL-6, NF-kB, COX-2, Prostaglandin-E2 in rheumatic rats

Noscapine hydrochloride (benzyl-isoquinoline alkaloid) effectively prevents protein denaturation through reduction of IL-6, NF-kB, COX-2, Prostaglandin-E2 in rheumatic rats

Noscapine hydrochloride (benzyl-isoquinoline antitussive alkaloid) is an opium derivative and generally used as a cough suppressant. Numerous studies on noscapine hydrochloride have reported that it has potent anti-inflammatory activity. However, the mechanisms by which it exerts an anti-inflammator...

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Bibliographic Details
Main Authors: Shanila Akhter, Hafiz Muhammad Irfan, Alamgeer, Aman Ullah, Shah Jahan, Muhammad Roman, Muhammad Bilal Latif, Zaid Mustafa, Farooq M. Almutairi, Yusuf S. Althobaiti
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Saudi Pharmaceutical Journal
Subjects:
Benzylisoquinoline alkaloids
Protein denaturation
Pro- and anti-inflammatory cytokines
Antioxidant
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016422002560

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http://www.sciencedirect.com/science/article/pii/S1319016422002560

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