Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis

Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis

The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis (NASH) remain largely unknown. We aimed to elucidate the roles of hepatic cyclooxygenase 1 (COX1) in autophagy and the pathogenesis of diet-induced steatohepatitis in mice. Human nonalcoholic fatty liver disease (NAFLD) liv...

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Bibliographic Details
Main Authors: Qian Yu, Chang Li, Qinghui Niu, Jigang Wang, Zhaodi Che, Ke Lei, He Ren, Boyi Ma, Yixing Ren, Pingping Luo, Zhuming Fan, Huan Zhang, Zhaohui Liu, George L. Tipoe, Jia Xiao
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Autophagy
Inflammation
Lipid metabolism
Nonalcoholic fatty liver disease
Cyclooxygenase 1
Phosphatidylinositol 3-phosphate
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523000977

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http://www.sciencedirect.com/science/article/pii/S2211383523000977

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