CDK12 orchestrates super‐enhancer‐associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer

CDK12 orchestrates super‐enhancer‐associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer

Abstract Background Hepatic metastasis is the primary and direct cause of death in individuals with colorectal cancer (CRC) attribute to lack of effective therapeutic targets. The present study aimed to identify potential druggable candidate targets for patients with liver metastatic CRC. Methods Th...

Full description

Bibliographic Details
Main Authors: Wei Dai, Junhong Wu, Xiaopeng Peng, Wen Hou, Hao Huang, Qilai Cheng, Zhiping Liu, Walter Luyten, Liliane Schoofs, Jingfeng Zhou, Shenglan Liu
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Clinical and Translational Medicine
Subjects:
CCDC137
CDK12
colorectal cancer
liver metastasis
super‐enhancers
Online Access:https://doi.org/10.1002/ctm2.1087

Internet

https://doi.org/10.1002/ctm2.1087

Similar Items