Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation

Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation

Abstract Engagement of the T cell receptor (TCR) triggers molecular reprogramming leading to the acquisition of specialized effector functions by CD4 helper and CD8 cytotoxic T cells. While transcription factors, chemokines, and cytokines are known drivers in this process, the temporal proteomic and...

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Bibliographic Details
Main Authors: Harshi Weerakoon, Ahmed Mohamed, Yide Wong, Jinjin Chen, Bhagya Senadheera, Oscar Haigh, Thomas S. Watkins, Stephen Kazakoff, Pamela Mukhopadhyay, Jason Mulvenna, John J. Miles, Michelle M. Hill, Ailin Lepletier
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-024-00346-4

Internet

https://doi.org/10.1038/s41540-024-00346-4

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