Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke

Abstract Stroke is a leading cause of mortality and morbidity with a paucity of effective pharmacological treatments. We have previously identified insulin-regulated aminopeptidase (IRAP) as a potential target for the development of a new class of drugs for the treatment of stroke, as global deletio...

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Bibliographic Details
Main Authors: Jonathon Telianidis, Andrew Hunter, Robert Widdop, Barbara Kemp-Harper, Vi Pham, Claudia McCarthy, Siew Yeen Chai
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-46072-5