Overcoming Immunological Challenges to Helper-Dependent Adenoviral Vector-Mediated Long-Term <i>CFTR</i> Expression in Mouse Airways

Overcoming Immunological Challenges to Helper-Dependent Adenoviral Vector-Mediated Long-Term <i>CFTR</i> Expression in Mouse Airways

Cystic Fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (<i>CFTR</i>) gene, and CF patients require life-long treatment. Although <i>CFTR</i> modulators show a great potential for treating most CF patients, some individuals may n...

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Bibliographic Details
Main Authors: Huibi Cao, Rongqi Duan, Jim Hu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Genes
Subjects:
cystic fibrosis
gene therapy
cyclophosphamide
transient immunosuppression
Online Access:https://www.mdpi.com/2073-4425/11/5/565

Internet

https://www.mdpi.com/2073-4425/11/5/565

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