Modeling patient-specific adenocarcinoma as spheroids enhances the authenticity of cancer hallmarks and therapeutic susceptibility

Modeling patient-specific adenocarcinoma as spheroids enhances the authenticity of cancer hallmarks and therapeutic susceptibility

Introduction: To help understand and develop treatments for cancer, it is important to have patient-specific, reliable and physiologically-relevant human culture models. Cells from solid tumors have traditionally been grown in 2-dimensional (2D) monolayers, however, it is known that cancer cells can...

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Bibliographic Details
Main Authors: Andres S. Espinoza, Rachael N. McVicar, Darren Finlay, Rabi Murad, Kristiina Vuori, Bethany A. Grimmig, Anne Bush, Emily Smith, Thomas Mandel-Clausen, Heather M. McGee, Evan Y. Snyder, Sandra L. Leibel
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Heliyon
Subjects:
Non-small cell lung cancer
Lung adenocarcinoma
Two-dimensional cancer models
Three-dimensional cancer models
Spheroids
Cancer hallmarks
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025013581

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http://www.sciencedirect.com/science/article/pii/S2405844025013581

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