Proteotranscriptomic analyses reveal distinct interferon-beta signaling pathways and therapeutic targets in choroidal neovascularization

Proteotranscriptomic analyses reveal distinct interferon-beta signaling pathways and therapeutic targets in choroidal neovascularization

AimTo investigate the molecular mechanism underlying the onset of choroidal neovascularization (CNV).MethodsIntegrated transcriptomic and proteomic analyses of retinas in mice with laser-induced CNV were performed using RNA sequencing and tandem mass tag. In addition, the laser-treated mice received...

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Bibliographic Details
Main Authors: Yuxiang Hu, Siyi Qi, Hong Zhuang, Qiao Zhuo, Yu Liang, Hongyu Kong, Chen Zhao, Shujie Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
immunity
inflammation
choroidal neovascularization (CNV)
interferon-β (IFN-β)
proteotranscriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1163739/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1163739/full

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